J Gastrointestin Liver Dis. 2025 Dec 26;34(4):481-486. doi: 10.15403/jgld-6465.
ABSTRACT
BACKGROUND AND AIMS: Acute pancreatitis (AP) presents with variable severity, and early identification of patients at risk for poor outcomes remains challenging. Red cell distribution width (RDW) is a widely available marker with potential prognostic value.
METHODS: We analyzed 682 patients from the RO-API/BUC-API registry admitted with AP between 2015 and 2023. RDW measured at 24±6 hours post-admission was assessed for associations with severity (per Revised Atlanta Classification) and in-hospital mortality. ROC analysis and logistic regression were applied.
RESULTS: Median RDW was significantly higher in non-survivors and patients with severe disease. RDW ≥13.85% predicted mortality [area under the curve (AUC)=0.67], and ≥14.35% predicted severe AP (AUC=0.67). RDW remained an independent predictor after adjusting for potential confounders.
CONCLUSIONS: RDW at 24 hours could be a useful early biomarker for predicting severity and mortality in AP.
PMID:41453089 | DOI:10.15403/jgld-6465