Rheumatol Ther. 2025 Dec 27. doi: 10.1007/s40744-025-00818-x. Online ahead of print.
ABSTRACT
INTRODUCTION: Psoriatic arthritis (PsA) is a heterogeneous, progressive inflammatory disease that often arises in patients with psoriasis. Increasing evidence highlights potential critical windows of opportunity during which early recognition and appropriate therapeutic intervention can alter long-term outcomes.
METHODS: This review summarizes evolving treatment strategies for PsA across the disease continuum-from psoriasis and very early PsA through to established disease-focusing on the rationale for rapid intervention and risk-stratified use of biologics and emerging therapies.
RESULTS: Data from many recent trials support the principle that earlier use of effective targeted therapy can improve outcomes, including controlling psoriasis and arthritis, inducing remission and even drug-free remission. Treat-to-target strategies, with close monitoring and timely escalation, are central to optimizing outcomes. In this recent literature, biologics targeting TNF, IL-17, and IL-23 have reshaped our understanding of the treatment landscape. Novel oral cytokine-signaling inhibitors, such as TYK2 and IL-23 receptor antagonists, represent promising future options but require long-term safety and head-to-head data in PsA. Comorbidities, patient preference, and safety considerations remain essential in tailoring therapy.
CONCLUSIONS: PsA management is shifting from reactive to proactive care. Aligning clinical practice toward early detection of skin and joint disease, rapid access to appropriate biologics, and disciplined treat-to-target approaches offer the best prospect for durable remission and improved quality of life. The next challenge lies in defining early PsA, predicting progression from psoriasis, and integrating new therapeutic classes into evidence-based treatment algorithms.
PMID:41455025 | DOI:10.1007/s40744-025-00818-x