Pediatr Infect Dis J. 2025 Dec 26. doi: 10.1097/INF.0000000000005120. Online ahead of print.ABSTRACTBACKGROUND: Premature and very low birth weight infants are at a greater risk of acquiring postnatal cytomegalovirus (CMV) infection and developing symptomatic disease, including a sepsis-like syndrom
Diseases. 2025 Nov 28;13(12):388. doi: 10.3390/diseases13120388.ABSTRACTBACKGROUND/OBJECTIVES: Sepsis-associated liver injury (SALI) is a critical and often early complication of sepsis, defined by distinct hyper-inflammatory and immunosuppressive phases that shape patient phenotypes.METHODS: Charac
Diseases. 2025 Nov 24;13(12):382. doi: 10.3390/diseases13120382.ABSTRACTNeutropenic patients with acute myeloid leukemia (AML) are at high risk for severe, multidrug-resistant infections. Sepsis due to carbapenem-resistant Pseudomonas aeruginosa (CRPA) in this population often leads to septic shock
J Vasc Surg Cases Innov Tech. 2025 Oct 8;12(1):102006. doi: 10.1016/j.jvscit.2025.102006. eCollection 2026 Feb.ABSTRACTDisseminated fungal infection resulting in aortic occlusion is a rare and highly morbid clinical phenomenon. This article reports the aortic occlusion of a 15-year-old male who had
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2025 Nov;37(11):1006-1012. doi: 10.3760/cma.j.cn121430-20241202-00980.ABSTRACTOBJECTIVE: To explore the possible mechanisms underlying the occurrence and development of sarcopenia in clinical sepsis patients based on proteomic sequencing, and to identify potent
CONCLUSIONS: Among sepsis patients, higher FiO(2) (> 0.80) is independently associated with an increased risk of 28-day mortality and hospital-acquired infection.Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2025 Nov;37(11):994-998. doi: 10.3760/cma.j.cn121430-20250621-00341.ABSTRACTOBJECTIVE: To analyze t
Nursing. 2026 Jan 1;56(1):36-39. doi: 10.1097/NSG.0000000000000298. Epub 2025 Dec 22.ABSTRACTInfection with Elizabethkingia species poses a significant illness risk to hospitalized patients and the public in general. This emerging opportunistic pathogen can infect the nervous system, pulmonary syste
Infect Immun. 2025 Dec 23:e0060425. doi: 10.1128/iai.00604-25. Online ahead of print.ABSTRACTIn a non-lethal, 10% total body surface area, full-thickness flame mouse model, infections with Pseudomonas aeruginosa (PA) increased mortality post-burn, suggesting an impaired host immune response. The pre
Medicine (Baltimore). 2025 Dec 19;104(51):e46352. doi: 10.1097/MD.0000000000046352.ABSTRACTRATIONALE: Pregnancy complicated by acquired immunodeficiency syndrome can result in a dual state of immune suppression, significantly increasing susceptibility to intracellular pathogens. Listeria monocytogen
Nat Commun. 2025 Dec 22. doi: 10.1038/s41467-025-67639-y. Online ahead of print.ABSTRACTHybrid vesicles are increasingly employed as nanocarrier systems for drug delivery owing to their versatile functionalities. This study presents a multifunctional vesicle delivery platform, designated PMB@LNV-SyB
JAMA Intern Med. 2025 Dec 22:e256919. doi: 10.1001/jamainternmed.2025.6919. Online ahead of print.ABSTRACTIMPORTANCE: Prolonged exposure to broad-spectrum antibiotics (BSA) may be associated with patient harm.OBJECTIVE: To assess outcomes of BSA de-escalation compared with continuation on encounter
Open Respir Arch. 2025 Oct 11;7(4):100503. doi: 10.1016/j.opresp.2025.100503. eCollection 2025 Oct-Dec.ABSTRACTWe report the first documented case of community-acquired pneumonia caused by Chryseobacterium gleum in an immunocompetent patient without typical risk factors. This gram-negative bacillus,
Front Microbiol. 2025 Dec 4;16:1707940. doi: 10.3389/fmicb.2025.1707940. eCollection 2025.ABSTRACTBACKGROUND: Pneumococcal infection, caused by Streptococcus pneumoniae, is a prevalent cause of community-acquired pneumonia and a major pathogen responsible for illnesses such as meningitis, sepsis, an
Infect Dis Ther. 2025 Dec 21. doi: 10.1007/s40121-025-01281-5. Online ahead of print.ABSTRACTInvasive meningococcal disease (IMD) in older adults frequently presents with atypical clinical manifestations, including bacteremic pneumonia, often without classical meningeal signs or sepsis, which presen
Rev Soc Bras Med Trop. 2025 Dec 15;58:e01762025. doi: 10.1590/0037-8682-0176-2025. eCollection 2025.ABSTRACTBACKGROUND: Arboviruses, including dengue (DENV), Zika (ZIKV), and chikungunya (CHIKV), pose serious threats to neonatal health; however, the consequences of maternal peripartum infections, pa
J Mater Chem B. 2025 Dec 19. doi: 10.1039/d5tb01110h. Online ahead of print.ABSTRACTA ubiquitous global threat of emerging multi-drug resistant (MDR) strains causing outbreaks of biofilm-mediated hospital-acquired infections (HAIs) has resulted in severe nosocomial contagious diseases, chronic wound
BMC Res Notes. 2025 Dec 19;18(1):505. doi: 10.1186/s13104-025-07576-7.ABSTRACTOBJECTIVE: Bloodstream infections (BSIs) are a common complication in hospitalized patients, but their incidence following open-heart surgery with delayed sternal closure (DSC) in infants with congenital heart disease (CHD
BMJ Case Rep. 2025 Dec 17;18(12):e268263. doi: 10.1136/bcr-2025-268263.ABSTRACTAn adolescent female patient presented to the Emergency Department of a large tertiary hospital in Ireland, with a 1-day history of chest and left axillary pain, and a 5-day history of productive cough, fever, reduced ora
Sci Rep. 2025 Dec 15;15(1):43788. doi: 10.1038/s41598-025-27649-8.ABSTRACTThis study aimed to compare the results of flow cytometric urine analysis and urine culture for the rapid diagnosis of urinary tract infections and to determine the leukocyte and bacterial cutoffs that could achieve maximum se
Sci Rep. 2025 Dec 15;15(1):43763. doi: 10.1038/s41598-025-27433-8.ABSTRACTCeftazidime, a third-generation cephalosporin, is effective for treating infections caused by gram-negative bacteria. However, increasing antibiotic resistance, particularly in multidrug-resistant gram-negative bacilli, compli
PeerJ. 2025 Dec 8;13:e20449. doi: 10.7717/peerj.20449. eCollection 2025.ABSTRACTBACKGROUND: Exploring the value of the neutrophil/lymphocyte ratio (NLR) as a potential supportive marker in community-acquired bloodstream infection in elderly patients.METHODS: By reviewing the data of inpatients in Xu
Nat Commun. 2025 Dec 12;16(1):11251. doi: 10.1038/s41467-025-66118-8.ABSTRACTHeteroresistance to vancomycin among methicillin-resistant Staphylococcus aureus (MRSA) remains a diagnostic and therapeutic problem in clinical microbiology. In this prospective cohort study of 842 adult patients with MRSA
Nat Commun. 2025 Dec 11. doi: 10.1038/s41467-025-67326-y. Online ahead of print.ABSTRACTRifaximin, a non-absorbable antibiotic used in managing recurrent hepatic encephalopathy (HE), has traditionally been considered low risk for inducing resistance. However, emerging evidence raised concerns that w
J Infect Dev Ctries. 2025 Nov 30;19(11):1656-1663. doi: 10.3855/jidc.20442.ABSTRACTINTRODUCTION: Klebsiella pneumoniae is a common causative agent of hospital-acquired (HA) bloodstream infections (BSI) in intensive care units (ICU). This study aimed to investigate mortality rates and the factors aff
