Integrated multi-omics profiling reveals immune-related biomarkers and regulatory networks for early prediction of tuberculosis in type 2 diabetes mellitus

Front Immunol. 2026 Feb 26;17:1755184. doi: 10.3389/fimmu.2026.1755184. eCollection 2026.ABSTRACTBACKGROUND: Type 2 diabetes mellitus (T2DM) significantly elevates the risk of tuberculosis (TB); however, early detection in T2DM patients is still insufficient. This study aimed to identify immune-base

Z Zhaoyang Ye

Differential mediation of depressive symptoms linking childhood adversity subtypes to chronic kidney disease: A focus on threat and deprivation

Child Abuse Negl. 2026 Mar 13;175:107987. doi: 10.1016/j.chiabu.2026.107987. Online ahead of print.ABSTRACTBACKGROUND: Adverse childhood experiences (ACEs) exhibit subtype-specific pathways to chronic kidney disease (CKD), yet the differential mediation by psychological distress remains unquantified

S Siyuan Wang

Systemic and Ocular Manifestations of a Ciliopathy: A Case Report of Renal-Retinal Involvement in Senior-Loken Syndrome

J Clin Med. 2026 Mar 8;15(5):2060. doi: 10.3390/jcm15052060.ABSTRACTBackground: Senior-Loken syndrome (SLS) is a rare autosomal recessive ciliopathy classically defined by the concurrence of nephronophthisis, frequently progressing to end-stage renal disease (ESRD), and retinal dystrophy, most commo

M Muzi Li

Burning Issues/Hot Topics: The Charcot Foot

J Clin Med. 2026 Mar 5;15(5):1993. doi: 10.3390/jcm15051993.ABSTRACTCharcot neuro-osteoarthropathy remains one of the most serious complications of diabetic neuropathy, with the potential for rapid progression to deformity, ulceration and limb-threatening outcomes. The earliest signs and symptoms ar

V Victoria E L Milbourn

Massive gastrointestinal stromal tumor with exophytic growth mimicking pelvic leiomyosarcoma: a case report and review of the literature

Int J Surg Case Rep. 2026 Jan 9;138(2):199-203. doi: 10.1097/RC9.0000000000000054. eCollection 2026 Feb.ABSTRACTINTRODUCTION: Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms of the gastrointestinal (GI) tract. Large, exophytically growing GISTs from the small bowel can present as m

A Ahmad Al-Bitar

A multimodal fusion model for bone tumor benign and malignant diagnosis: development and validation with clinical text and radiographs

Transl Cancer Res. 2026 Feb 28;15(2):91. doi: 10.21037/tcr-2025-1832. Epub 2026 Feb 2.ABSTRACTBACKGROUND: Bone tumors have diverse clinical and imaging features, rendering preoperative differentiation of benign, intermediate/malignant types challenging. Unimodal methods (medical records or X-rays) a

J Ju Zeng

Construction and validation of a palmitoylation-related prognostic model for lung adenocarcinoma based on integrated bioinformatics and machine learning

Transl Cancer Res. 2026 Feb 28;15(2):98. doi: 10.21037/tcr-2025-1389. Epub 2026 Feb 12.ABSTRACTBACKGROUND: Lung adenocarcinoma (LUAD) is a prevalent malignancy whose therapeutic management is complicated by nonspecific early symptoms, late-stage diagnosis, and aggressive metastasis. Given the critic

Z Zhilan Huang

Advances in non-invasive biomarkers for pediatric inflammatory bowel disease diagnosis

World J Gastroenterol. 2026 Mar 7;32(9):116223. doi: 10.3748/wjg.v32.i9.116223.ABSTRACTPediatric inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), presents significant diagnostic challenges due to its heterogeneous clinical presentation and reliance on inv

L Li Zheng

Clinical Utility of Peripheral Non-Enzymatic Antioxidants in Differentiating Major Depressive Disorder from Bipolar Disorder: Associations with Antioxidant Levels, Hospitalization Outcomes, and Antidepressant Efficacy

Neuropsychiatr Dis Treat. 2026 Mar 4;22:585769. doi: 10.2147/NDT.S585769. eCollection 2026.ABSTRACTOBJECTIVE: To investigate changes in peripheral blood non-enzymatic antioxidant levels in patients with major depressive disorder (MDD) and bipolar disorder (BD) across different disease stages from a

J Jiangjing Dai

ADHD With and Without Comorbid Specific Learning Disorder: Comparisons of WISC-R Profiles, Cognitive Disengagement and Psychiatric Symptoms

Int J Dev Neurosci. 2026 Apr;86(2):e70109. doi: 10.1002/jdn.70109.ABSTRACTBACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) and specific learning disorder (SLD) are neurodevelopmental conditions, and cognitive disengagement syndrome (CDS) is a related symptom construct that frequently co-o

S Seda Bozduman Çelebi

Focal "Targetoid" liver lesions on MRI: a diagnostic and practical imaging approach

Abdom Radiol (NY). 2026 Mar 9. doi: 10.1007/s00261-026-05383-7. Online ahead of print.ABSTRACTTargetoid liver lesions exhibit a characteristic MRI appearance, with differential signal intensity and enhancement between the central and peripheral components. This imaging pattern is observed across a w

I Ignacio Maldonado Schoijet

Neurological Infections in HIV: A Case-Based Review for Clinicians

Infez Med. 2026 Mar 1;34(1):12-27. doi: 10.53854/liim-3401-2. eCollection 2026.ABSTRACTCentral Nervous System (CNS) disease remains a significant cause of morbidity and mortality in people with advanced HIV infection. This case-based review presents eight illustrative scenarios to demonstrate a stru

N Nitin Gupta

Schwannoma: a spectrum from benign to malignant

Rom J Morphol Embryol. 2025 Oct-Dec;66(4):673-681. doi: 10.47162/RJME.66.4.05.ABSTRACTPeripheral nerve sheath tumors are a group of neoplasms that arise from Schwann cells. This study evaluates the histopathological and immunohistochemical (IHC) characteristics of these entities, spanning a spectrum

A Andreea Cătălina Tinca

Differential Diagnosis of Eosinophilic Lung Diseases

J Allergy Clin Immunol Pract. 2026 Mar;14(3):542-557. doi: 10.1016/j.jaip.2026.01.027.ABSTRACTEosinophilic lung diseases encompass a heterogeneous spectrum of disorders characterized by the accumulation of eosinophils within the lung parenchyma. Etiologies range from primary eosinophilic syndromes t

G Giacomo Emmi

Kawasaki disease vs. MIS-C in a child with congenital coronary artery anomaly: a case report

Front Pediatr. 2026 Feb 17;14:1768080. doi: 10.3389/fped.2026.1768080. eCollection 2026.ABSTRACTKawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C), associated with SARS-CoV-2 infection share overlapping clinical and laboratory features, making differential diagnosis part

O Oksana Boyarchuk

Idiopathic granulomatous mastitis: A narrative review based on the Turkish consensus classification

Turk J Surg. 2026 Mar 5;42(1):1-12. doi: 10.47717/turkjsurg.2026.2025-8-40. Epub 2026 Mar 2.ABSTRACTIdiopathic granulomatous mastitis (IGM) is a rare, heterogeneous inflammatory breast disease lacking a universally accepted classification or a standardized management pathway. To provide a comprehens

M Mustafa Emiroğlu

Towards a Biologically Defined Diagnosis: Incorporating Pathophysiological Measures Into Parkinson's Disease Clinical Criteria

Parkinsons Dis. 2026 Feb 25;2026:2703114. doi: 10.1155/padi/2703114. eCollection 2026.ABSTRACTParkinson's disease is the second most common neurodegenerative disorder worldwide, as well as being the fastest-growing neurological disorder. Furthermore, PD corresponds to a significant burden on those d

A Angus McNamara

Clinical Outcomes and Molecular Epidemiology of Human Metapneumovirus in Romanian Hospitalized Patients

Microorganisms. 2026 Feb 8;14(2):403. doi: 10.3390/microorganisms14020403.ABSTRACTHuman metapneumovirus (hMPV) is an important cause of acute respiratory tract infections. This study aimed to describe the clinical characteristics, outcomes, and molecular features of hMPV infection among hospitalized

O Ovidiu Vlaicu

Impact of a Neurogenic Dysphagia Outpatient Clinic on Diagnosis, Treatment, and Nutrition

Eur J Neurol. 2026 Mar;33(3):e70544. doi: 10.1111/ene.70544.ABSTRACTBACKGROUND: The aim was to evaluate the diagnostic, therapeutic, nutritional, and complication-related impact of a university-led neurogenic dysphagia outpatient clinic.METHODS: We retrospectively analyzed all patients seen at the U

B Bendix Labeit

Identification of the Philadelphia-like subgroup in Turkish pediatric patients with acute lymphoblastic leukemia

Ann Hematol. 2026 Feb 25;105(4):138. doi: 10.1007/s00277-026-06845-0.ABSTRACTPh-like ALL, a high-risk subgroup of B-cell ALL, is associated with a poor prognosis. The genetic diversity observed across different ethnicities underscores the importance of population-specific studies to gain a deeper un

E Ecem Efendi Erdem

Serum biomarker screening and metabolic profiling analysis of nonalcoholic fatty liver disease patients using untargeted metabolomics and machine learning techniques

Front Mol Biosci. 2026 Feb 9;13:1730023. doi: 10.3389/fmolb.2026.1730023. eCollection 2026.ABSTRACTBACKGROUND AND OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) represents the most prevalent chronic hepatic metabolic disorder globally. Without timely intervention, it can progress to non-alcoho

L Lijuan Dan

Loss of Methylthioadenosine Phosphorylase (MTAP) Expression: A Potentially Useful Tool for Distinguishing Sarcomatoid Urothelial Carcinoma From Inflammatory Myofibroblastic Tumor

Mod Pathol. 2026 Feb 21;39(4):100980. doi: 10.1016/j.modpat.2026.100980. Online ahead of print.ABSTRACTInflammatory myofibroblastic tumor (IMT) and sarcomatoid urothelial carcinoma (SarUC) can have striking histologic overlap but have significantly different prognoses and clinical management paradig

H Huili Li

Imaging of intrauterine contraceptive devices: a comprehensive pictorial review

Abdom Radiol (NY). 2026 Feb 23. doi: 10.1007/s00261-026-05392-6. Online ahead of print.ABSTRACTIntrauterine contraceptive devices (IUCDs) are widely used, highly effective, and reversible methods of contraception. Despite their overall safety profile, IUCD malposition and complications May occur and

C Camila Braga Visconti

IgG4-related sclerosing cholangitis: navigating diagnostic dilemmas and the challenge of relapse

Front Med (Lausanne). 2026 Feb 5;13:1732637. doi: 10.3389/fmed.2026.1732637. eCollection 2026.ABSTRACTBACKGROUND: Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC), also termed IgG4-related cholangitis (IRC), is a challenging immune-mediated biliary disease, frequently mimicking malignancie

X Xiangxiang Ren