Geroscience. 2025 Dec 27. doi: 10.1007/s11357-025-02049-y. Online ahead of print.ABSTRACTDifficult-to-treat rheumatoid arthritis (D2T RA) is an emerging challenge in aging populations, where disease persistence and therapeutic failure often reflect not only autoimmune dysregulation but also the cumu
Cureus. 2025 Nov 24;17(11):e97640. doi: 10.7759/cureus.97640. eCollection 2025 Nov.ABSTRACTThe rising prevalence of multimorbidity, defined as the coexistence of two or more chronic health conditions, is particularly pronounced among older adults and often necessitates polypharmacy. This increases t
Sci Rep. 2025 Dec 24;15(1):44608. doi: 10.1038/s41598-025-28382-y.ABSTRACTFrailty is a multidimensional syndrome of aging increasingly studied in companion dogs. Two main operational models have been developed: the frailty phenotype, based on five clinical criteria, and the frailty index, derived fr
J Manag Care Spec Pharm. 2026 Jan;32(1):85-94. doi: 10.18553/jmcp.2026.32.1.85.ABSTRACTBACKGROUND: The Medicare Part D Medication Therapy Management (MTM) program uses comprehensive medication reviews (CMRs) and targeted medication reviews to address medication-related problems in older adults. One
Addiction. 2025 Dec 24. doi: 10.1111/add.70306. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Persons who inject drugs (PWID) experience a high burden of early-onset frailty, primarily due to multifactorial causes such as infections (human immunodeficiency virus [HIV], hepatitis C virus [HCV]),
Urologie. 2025 Dec 23. doi: 10.1007/s00120-025-02750-y. Online ahead of print.ABSTRACTBACKGROUND: Modern treatments in uro-oncology are increasingly based on therapeutics with complex metabolism in the human body and are associated with an increased risk of drug interactions.OBJECTIVE: This article
Alzheimers Dement. 2025 Dec;21 Suppl 8(Suppl 8):e110066. doi: 10.1002/alz70862_110066.ABSTRACTBACKGROUND: Quantifying tau aggregates in the human brain can be achieved using Positron Emission Tomography (PET) techniques, which can potentially be affected by binding competition due to medication use.
Front Med (Lausanne). 2025 Dec 5;12:1673885. doi: 10.3389/fmed.2025.1673885. eCollection 2025.ABSTRACTOBJECTIVE: As a core indicator of healthy aging, intrinsic capacity (IC) may be adversely impacted by polypharmacy. Leveraging data from the WHO Integrated Care for Older People (ICOPE) pilot in Chi
Front Pharmacol. 2025 Dec 5;16:1601450. doi: 10.3389/fphar.2025.1601450. eCollection 2025.ABSTRACTBACKGROUND: Drug-induced cytopenias are serious adverse drug reactions (ADRs), often challenging to diagnose. While causality algorithms offer high sensitivity and positive predictive values, they exhib
Eur Geriatr Med. 2025 Dec 19. doi: 10.1007/s41999-025-01389-4. Online ahead of print.ABSTRACTPURPOSE: The average age of people living with HIV in Europe is rising and with it the likelihood of entering long-term care. Little is known about the characteristics of people living with HIV in care homes
Health Sci Rep. 2025 Dec 17;8(12):e71664. doi: 10.1002/hsr2.71664. eCollection 2025 Dec.ABSTRACTBACKGROUND AND AIMS: Hospital undernutrition is a major problem affecting the health of adult and elderly patients. The aim of this study was to contribute to the nutritional care of adults and elderly pe
Palliat Care Soc Pract. 2025 Dec 15;19:26323524251403020. doi: 10.1177/26323524251403020. eCollection 2025.ABSTRACTBACKGROUND: Potentially inappropriate medications (PIMs) pose a significant burden on patients with advanced cancer approaching the end of life. However, trends in the prescription of P
BMC Geriatr. 2025 Dec 17. doi: 10.1186/s12877-025-06545-w. Online ahead of print.ABSTRACTBACKGROUND: Polypharmacy is associated with increased risk of adverse events and may increase healthcare expenditures. However, there is a lack of study using nationally representative data to assess additional
Age Ageing. 2025 Nov 28;54(12):afaf360. doi: 10.1093/ageing/afaf360.ABSTRACTBACKGROUND: The rapid ageing of South Korea has led to a growing use of sedative-hypnotic drugs (SHDs) amongst older people, raising concerns about SHD polypharmacy and the increased risk of falls or fractures.OBJECTIVE: Thi
Front Endocrinol (Lausanne). 2025 Dec 1;16:1724965. doi: 10.3389/fendo.2025.1724965. eCollection 2025.ABSTRACTCardiometabolic multimorbidity (CMM), defined as the simultaneous presence of two or more cardiovascular and metabolic diseases in an individual, including but not limited to type 2 diabetes
Eur J Prev Cardiol. 2025 Dec 16:zwaf769. doi: 10.1093/eurjpc/zwaf769. Online ahead of print.ABSTRACTAIM: To estimate the prevalence of good adherence to statin therapy and identify demographic and clinical factors associated with adherence among adults prescribed lipid-lowering therapy (LLT) for ath
Ir J Med Sci. 2025 Dec 16. doi: 10.1007/s11845-025-04228-4. Online ahead of print.ABSTRACTBACKGROUND: Antipsychotics are the cornerstone of psychotic disorder treatment, often used in combination with other psychotropics. However, real-world data on inpatient treatment in Türkiye remain scarce.AIM:
J Eval Clin Pract. 2025 Dec;31(8):e70330. doi: 10.1111/jep.70330.ABSTRACTBACKGROUND: Intrinsic capacity (IC) is a clinically meaningful and potentially modifiable outcome that predicts dependence, hospital admission, and mortality in older adults. Research on the relationships among polypharmacy, po
J Assoc Physicians India. 2025 Dec;73(12):17-22. doi: 10.59556/japi.73.1262.ABSTRACTBACKGROUND: Hydration plays a vital role in metabolic health, particularly in diabetes, where factors such as osmotic diuresis, polypharmacy, and comorbidities heighten the risk of dehydration. Effective management o
Ig Sanita Pubbl. 2025 Sep-Oct;98(5):285-300.ABSTRACTBACKGROUND: The global rise in the ageing population has increased the burden of chronic oral diseases among older adults, particularly in regions with limited geriatric-focused healthcare resources. Age-related physiological decline, multimorbidit
Eur J Heart Fail. 2025 Dec 11. doi: 10.1002/ejhf.70087. Online ahead of print.ABSTRACTHeart failure (HF) exerts a global health burden, often complicated by polypharmacy due to the frequent coexistence of cardiovascular and non-cardiovascular comorbidities. While guideline-directed medical therapy a
Med Oncol. 2025 Dec 12;43(1):52. doi: 10.1007/s12032-025-03193-3.ABSTRACTCutaneous toxicity is one of the most frequent and visible complications of modern cancer therapy and a major determinant of quality of life, adherence and dose intensity. This narrative review summarizes current knowledge on t
Epilepsy Behav. 2025 Dec 10;175:110829. doi: 10.1016/j.yebeh.2025.110829. Online ahead of print.ABSTRACTOBJECTIVE: The drivers of chronic disease in people with epilepsy with epilepsy (PWE) are unknown. We aimed to identify the role of health risk factors, polypharmacy, and medication usage in (PWE)
Gerontology. 2025 Dec 11:1-20. doi: 10.1159/000550017. Online ahead of print.ABSTRACTINTRODUCTION: Polypharmacy might be clinically appropriate if it improves health outcomes of people with dementia. However, polypharmacy was associated with higher risks of impairment in cognitive, physical, and emo
