Nat Commun. 2025 Dec 29. doi: 10.1038/s41467-025-67688-3. Online ahead of print.ABSTRACTCancer detection is challenging, especially in patients with diffuse symptoms that overlap with non-malignant conditions. Here we show that plasma protein profiling can identify cancer among patients with non-spe
Exp Gerontol. 2025 Dec 26:113015. doi: 10.1016/j.exger.2025.113015. Online ahead of print.ABSTRACTImmunonutrition refers to nutritional interventions that can improve immune function. The nutritional contents used in immunocytes include amino acids, vitamins, minerals, and flavonoids. In this study,
Joint Bone Spine. 2025 Dec 26:106028. doi: 10.1016/j.jbspin.2025.106028. Online ahead of print.ABSTRACTMusculoskeletal manifestations of transthyretin amyloidosis (ATTR) are common, early in the disease course (usually years before cardiac involvement), and are potentially predictive. They include c
J Health Psychol. 2025 Dec 26:13591053251400827. doi: 10.1177/13591053251400827. Online ahead of print.ABSTRACTAutoimmune inflammatory rheumatic diseases (AIRDs) pose significant challenges due to persistent symptoms, such as pain, fatigue, and psychological distress (i.e. anxiety and depression). L
Geroscience. 2025 Dec 27. doi: 10.1007/s11357-025-02049-y. Online ahead of print.ABSTRACTDifficult-to-treat rheumatoid arthritis (D2T RA) is an emerging challenge in aging populations, where disease persistence and therapeutic failure often reflect not only autoimmune dysregulation but also the cumu
Sci Rep. 2025 Dec 26. doi: 10.1038/s41598-025-33927-2. Online ahead of print.ABSTRACTAlopecia areata (AA) is an easy-recurring disease that presents huge challenges globally. An efficient clinical tool to predict AA onset would be valuable for timely intervention. We extracted six AA-related dataset
J Invest Dermatol. 2025 Dec 24:S0022-202X(25)03684-X. doi: 10.1016/j.jid.2025.12.015. Online ahead of print.ABSTRACTPsoriasis vulgaris is a T cell-mediated autoimmune skin condition affecting around one in fifty people worldwide. Whilst advanced immunomodulatory therapeutic options have become avail
Autoimmun Rev. 2025 Dec 24;25(2):103977. doi: 10.1016/j.autrev.2025.103977. Online ahead of print.ABSTRACTTissue-resident memory T (Trm) cells, once heralded as gatekeepers of localized immune protection, have emerged as central players in the pathogenesis of chronic inflammation and autoimmunity at
Br J Dermatol. 2025 Dec 26:ljaf526. doi: 10.1093/bjd/ljaf526. Online ahead of print.ABSTRACTThe cGAS-STING pathway is an evolutionary conserved pathway for sensing and responding to DNA either pathogen-associated or endogenous DNA. DNA is sensed by cGAS and this enzymatically generates the second me
Probiotics Antimicrob Proteins. 2025 Dec 26. doi: 10.1007/s12602-025-10889-5. Online ahead of print.ABSTRACTInflammation triggered by injury, infection, or exposure to chemicals results in chronic diseases, and constitutes the leading cause of death worldwide. Anti-inflammatory drugs available for t
Med Oncol. 2025 Dec 26;43(2):95. doi: 10.1007/s12032-025-03211-4.ABSTRACTCancer cells show abnormal nucleotide metabolism and prefer the de novo synthesis pathway. As the key enzymes, Carbamoyl-phosphate synthetase 2, Aspartate transcarbamoylase, and Dihydroorotase (CAD) is overactivated in cancer a
Arthritis Rheumatol. 2025 Dec 26. doi: 10.1002/art.70046. Online ahead of print.ABSTRACTOBJECTIVE: Phenotypic diversity of autoimmune diseases presents an ongoing diagnostic and therapeutic challenge. The discovery of mutations in RELA (encoding RELA/p65) in patients with diverse disease phenotypes
Radiol Case Rep. 2025 Dec 6;21(3):959-963. doi: 10.1016/j.radcr.2025.11.046. eCollection 2026 Mar.ABSTRACTIgG4-related disease (IgG4-RD) is a fibro-inflammatory autoimmune disorder with an incompletely understood pathophysiology. This condition can affect a wide range of organs, and its hallmark fea
Front Immunol. 2025 Dec 10;16:1675131. doi: 10.3389/fimmu.2025.1675131. eCollection 2025.ABSTRACTINTRODUCTION: Familial Mediterranean fever (FMF) and celiac disease (CD) are both immune-mediated disorders that may share overlapping inflammatory mechanisms. This study aimed to evaluate the clinical f
Front Immunol. 2025 Dec 10;16:1688916. doi: 10.3389/fimmu.2025.1688916. eCollection 2025.ABSTRACTINTRODUCTION: Glycosphingolipids (GSLs), including hexosylceramides (HexCers), lactosylceramides (LacCers), and gangliosides composed of one or more sugar residues attached to ceramide, are essential com
Cureus. 2025 Nov 23;17(11):e97586. doi: 10.7759/cureus.97586. eCollection 2025 Nov.ABSTRACTSystemic lupus erythematosus (SLE) is a chronic autoimmune disease associated with significant maternal and fetal risks during pregnancy. Lupus nephritis further increases morbidity, while neurological complic
Mater Today Bio. 2025 Dec 2;35:102613. doi: 10.1016/j.mtbio.2025.102613. eCollection 2025 Dec.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent joint inflammation and swelling. Neutrophils play pivotal roles in the pathogenesis of RA and represent potentia
Adv Sci (Weinh). 2025 Dec 25:e15675. doi: 10.1002/advs.202515675. Online ahead of print.ABSTRACTAutoimmune inflammatory diseases (AIDs) are genetically linked disorders with unclear causal links to brain functional networks. Using bidirectional two-sample Mendelian randomization (MR) on GWAS data fr
Trends Cardiovasc Med. 2025 Dec 23:S1050-1738(25)00163-X. doi: 10.1016/j.tcm.2025.12.005. Online ahead of print.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is a genetically determined myocardial disease characterized by myocyte loss, fibro-fatty replacement, and electrical instability. In a subset o
Ther Adv Neurol Disord. 2025 Dec 21;18:17562864251401496. doi: 10.1177/17562864251401496. eCollection 2025.ABSTRACTBACKGROUND: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is the most frequently observed autoimmune neuropathy in patients with diabetes mellitus (DM). While intrave
J Voice. 2025 Dec 23:S0892-1997(25)00523-5. doi: 10.1016/j.jvoice.2025.11.042. Online ahead of print.ABSTRACTBACKGROUND: Laryngotracheal stenosis (LTS) involves narrowing of the proximal upper airway that can cause obstructed airflow and respiratory distress. LTS can be caused by intubation, previou
Free Radic Biol Med. 2025 Dec 22;245:30-42. doi: 10.1016/j.freeradbiomed.2025.12.033. Online ahead of print.ABSTRACTBACKGROUND: Systemic sclerosis (SSc), or scleroderma, is an autoimmune disease with localized/diffuse skin thickening and fibrosis as main features, where disease progression links to
Mult Scler Relat Disord. 2025 Dec 16;107:106936. doi: 10.1016/j.msard.2025.106936. Online ahead of print.ABSTRACTBACKGROUND: Multiple Sclerosis (MS) is a complex autoimmune inflammatory disease of the central nervous system with an incompletely understood etiology. Emerging evidence suggests a criti
Cytokine. 2025 Dec 23;198:157098. doi: 10.1016/j.cyto.2025.157098. Online ahead of print.ABSTRACTAutoimmune diseases result from dysregulated immune responses, primarily driven by CD4+ T cell imbalances, leading to chronic inflammation and tissue destruction. Conventional cytokine-based therapies, i
