Ann Rheum Dis. 2026 Mar 17:S0003-4967(26)00088-9. doi: 10.1016/j.ard.2026.02.013. Online ahead of print.ABSTRACTOBJECTIVES: Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by dysregulation of the adaptive and innate immunity. This study aimed to identify transcriptomic diff
Lupus Sci Med. 2026 Mar 18;13(1):e001830. doi: 10.1136/lupus-2025-001830.ABSTRACTOBJECTIVES: To define a clinically meaningful treatment response definition for haemolytic anaemia, that will form part of a novel multidomain outcome measure for SLE clinical trials.METHODS: An international working gr
Eur J Med Chem. 2026 Mar 13;309:118778. doi: 10.1016/j.ejmech.2026.118778. Online ahead of print.ABSTRACTRetinoic acid receptor-related orphan receptor γ (RORγ) is a key transcriptional regulator of the T helper 17 cell and has emerged as a promising therapeutic target for autoimmune diseases. To id
Cell Rep. 2026 Mar 17;45(4):117123. doi: 10.1016/j.celrep.2026.117123. Online ahead of print.ABSTRACTT helper 17 (Th17) cells are pivotal in mucosal defense and autoimmune pathology, with their function governed by the transcription factor retinoic acid receptor-related orphan receptor gamma t (RORγ
Z Rheumatol. 2026 Mar 18. doi: 10.1007/s00393-026-01797-2. Online ahead of print.ABSTRACTBACKGROUND: Primary Sjögren's disease (SjD) is a chronic autoimmune disease that predominantly affects exocrine glands but can also show numerous systemic organ manifestations.OBJECTIVE: Presentation of the curr
Ann Plast Surg. 2026 Mar 19. doi: 10.1097/SAP.0000000000004731. Online ahead of print.ABSTRACTBACKGROUND: Invasive and minimally invasive cosmetic procedures in patients with autoimmune or inflammatory skin disorders can carry an increased risk of surgical site infection, disease exacerbation, atrop
Immun Inflamm Dis. 2026 Mar;14(3):e70377. doi: 10.1002/iid3.70377.ABSTRACTBACKGROUND: Patients with autoimmune disorders are highly susceptible to infections including cytomegalovirus (CMV) leading to serious complications ranging from asymptomatic to severe systemic diseases.CASE PRESENTATION: The
J Immunol. 2026 Mar 17;215(3):vkaf348. doi: 10.1093/jimmun/vkaf348.ABSTRACTIL-12p40 heterodimerizes with IL-12p19 and IL-12p35 to produce IL-23 and IL-12, respectively. The functions of IL-12 and IL-23 are best described in T cells in which IL-12 is a potent inducer of Th1 differentiation, whereas I
Vitamin D(3) (VitD(3)) deficiency affects over one billion individuals globally, representing a critical modifiable risk factor for immune-mediated diseases. Beyond its classical role in calcium metabolism, Vitamin D(3) orchestrates immune homeostasis through vitamin D receptor (VDR) signaling, exer
Front Immunol. 2026 Mar 2;17:1713221. doi: 10.3389/fimmu.2026.1713221. eCollection 2026.ABSTRACTSystemic sclerosis (SSc) is a chronic autoimmune disease characterized by immune dysregulation, microvascular damage, and multi-organ fibrosis. Recent breakthroughs in single-cell and spatial multi-omics
Front Immunol. 2026 Mar 2;17:1711854. doi: 10.3389/fimmu.2026.1711854. eCollection 2026.ABSTRACTAtopic dermatitis (AD) is a common and chronic inflammatory skin disease characterized by an abnormal skin barrier, resulting in skin dryness, pruritus, and an increased risk of allergies and secondary in
Cureus. 2026 Feb 13;18(2):e103550. doi: 10.7759/cureus.103550. eCollection 2026 Feb.ABSTRACTWe present the case of a 57-year-old woman with severe, recurrent oral ulceration and weight loss. Faecal calprotectin was markedly elevated at 1,246 µg/g, initially raising suspicion of inflammatory bowel di
Int Immunopharmacol. 2026 Mar 16;177:116509. doi: 10.1016/j.intimp.2026.116509. Online ahead of print.ABSTRACTThe DNA damage response (DDR) is considered a pivotal regulator of immune activation, in which genomic stress serves as an interface between genomic biochemistry and innate and adaptive immu
Klin Monbl Augenheilkd. 2026 Mar 17. doi: 10.1055/a-2685-3349. Online ahead of print.ABSTRACTThe term optic neuritis describes an inflammation of the optic nerve. It encompasses a group of different diseases that vary in their prevalence, clinical course, treatment, and visual prognosis. These inclu
Curr Opin Immunol. 2026 Mar 16;100:102754. doi: 10.1016/j.coi.2026.102754. Online ahead of print.ABSTRACTNon-communicable diseases, including metabolic, inflammatory, and malignant disorders, now dominate global morbidity and mortality. These chronic, lifestyle-associated diseases expose the limits
Cardiovasc Res. 2026 Mar 17:cvag057. doi: 10.1093/cvr/cvag057. Online ahead of print.ABSTRACTAIMS: Acute myocarditis is an immune-mediated inflammatory disease characterized by myocardial inflammation and edema. Although cardiac lymphatic vessels are essential for fluid clearance and immune regulati
Saudi Pharm J. 2026 Mar 17;34(2):14. doi: 10.1007/s44446-026-00063-5.ABSTRACTAdalimumab is a monoclonal antibody approved for managing inflammatory bowel disease (IBD) and other autoimmune conditions. Biosimilars can offer a more affordable alternative to reference biologics and improve access to tr
Microbiol Spectr. 2026 Mar 17:e0258825. doi: 10.1128/spectrum.02588-25. Online ahead of print.ABSTRACTColistin is a crucial antibiotic for treating infections caused by multidrug-resistant Enterobacterales. However, the emergence of plasmid-mediated mcr genes has significantly compromised their clin
Clin Exp Rheumatol. 2026 Mar 12. doi: 10.55563/clinexprheumatol/t7zeld. Online ahead of print.ABSTRACTOBJECTIVES: Juvenile idiopathic arthritis (JIA) leads to significant long-term morbidity from articular and extra-articular complications, yet the burden of comorbidities in adults with long-standin
Clin Exp Rheumatol. 2026 Mar 12. doi: 10.55563/clinexprheumatol/0bkrx5. Online ahead of print.ABSTRACTCentral memory T (TCM) cells are a cornerstone of the adaptive immune system, serving as a long-lived, self-renewing stem-like population that provides durable immunological protection. Primarily re
FEBS J. 2026 Mar 17. doi: 10.1111/febs.70490. Online ahead of print.ABSTRACTCyclic GMP-AMP synthase (cGAS) senses cytosolic self and microbial DNA to produce cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), a secondary messenger that activates the endoplasmic reticulum-resident transm
Cureus. 2026 Feb 11;18(2):e103440. doi: 10.7759/cureus.103440. eCollection 2026 Feb.ABSTRACTTransverse myelitis (TM) is an acquired inflammatory disorder of the spinal cord with a heterogeneous aetiology that includes demyelinating, autoimmune, infectious, granulomatous, and paraneoplastic causes. A
Autoimmun Rev. 2026 Mar 14:104035. doi: 10.1016/j.autrev.2026.104035. Online ahead of print.ABSTRACTPhosphodiesterase (PDE) inhibitors are a class of pharmacological agents that regulate immune and vascular function by controlling the intracellular concentration of key second messengers. By modulati
Presse Med. 2026 Mar 14:104340. doi: 10.1016/j.lpm.2026.104340. Online ahead of print.ABSTRACTEven though immune checkpoint inhibitors (ICI) remain effective treatments for an increasing number of cancers, they are also liable to cause immune-related adverse events (irAE). Rheumatologic manifestatio
