Rev Esp Enferm Dig. 2026 Mar 18. doi: 10.17235/reed.2026.11866/2026. Online ahead of print.
ABSTRACT
This letter meaningfully expands the recent Cayuela et al study published in this journal by situating Spain's observed early-onset gastrointestinal cancer trends within a robust global framework, using GLOBOCAN projections to distinguish declining age-standardised risk from shifting absolute burden driven by demographic change. By integrating HDI-stratified forecasts for early-onset stomach and oesophageal cancers, it reinforces the authors' interpretation of early-onset malignancies as sentinel indicators while avoiding overextension of national findings. Together, the study and this correspondence provide a more complete, policy-relevant narrative that links successful national prevention to emerging global inequities and future cancer control priorities.
PMID:41848080 | DOI:10.17235/reed.2026.11866/2026